Rochester Clinical Research is currently enrolling for a knee pain study. The purpose of the study is to test the efficacy of an injection compared to a placebo injection to treat osteoarthritis of the knee. We are seeking participants between the ages of 21-80 years old who have experienced osteoarthritis of the knee for at least 6 months. The study is 12 months long but there is a possible extension for another 6 months. Ten office visits will be required and compensation will be available for your participation.