About The Study:

Obesity is a chronic disease and has an increasing prevalence as a public health concern associated with the rising numbers of individuals getting Type 2 Diabetes and increased risk for premature death and some cancers. Lifestyle interventions in the form of diet and exercise are always the first line of treatment for obesity, but it is difficult to achieve and maintain weight loss. Surgical treatments also offer an effective alternative for some people with severe obesity, but surgery carries a large risk of complications. Our current weight loss study is trying to investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity.

Do you have a history of high blood pressure, low HDL levels, heart attack, stroke, Coronary artery bypass, or are a current smoker? Have you tried everything to lose weight to prevent these problems from happening again? RCR is looking for people with certain health conditions that obesity can add more complications to.

Please note, our weight loss studies involve an intensive lifestyle change with diet and exercise counseling.

Compensation is available for time and travel is available for those who qualify. Study-related care is available to participants at no cost and health insurance is not required nor needed.


Key Information About The Study From Our Registered Dietician:

Everyone that joins the study will be expected to work to improve their nutrition by making better food choices, eating less and exercising and/or moving more/being more active.
We don’t advocate any fad diets, but just trying to consume 500 fewer calories than their body needs to promote slow weight loss. We have a calculation based on a person’s sex, body weight, and height that tells us about how many calories a person needs to maintain their current weight. From that figure we take 500 calories away, and that becomes their “calorie goal”.
We ask that all participants keep a food diary. We recommend doing it electronically on a phone or computer. This allows the Registered Dietician to review what the person is eating and then make suggestions for improvements.  Research has shown when people write down their food intake, they are more successful at weight loss. It ‘s not just about calories, but also looking to see if patients are eating well, meaning enough protein, fiber and key nutrients. The dietary suggestions that are given are individualized based on the patients medical history (history of osteoporosis)  food allergies or intolerances (milk or gluten allergy). It is not a one size fits all diet however the overall arching concept is eating less and counting calories.
I always tried to incorporate ideas based on the Mediterranean diet and have worked to incorporate other techniques such as intermittent fasting (timed eating) when appropriate or insisted upon. It is not however a diet that advocates 3-4 day fasts, only protein foods, etc.
Everyone will be expected and encouraged to move and get more activity and or exercise. The standard is building up to 150 minutes per week. They don’t have to be doing any exercise to start the program but they have to be WILLING to start.
This is also very individualized since some people are already exercising a lot more than that and some have not gone out for a walk in months.
Again, we try to work with the patient at their level and what they are able and willing to do. I think the biggest concern with this study is to find out if a patient has any restrictions on exercise and that is something I ask about when I call them.
It doesn’t matter if patients get the placebo or the active drug. Yes, if they get the drug they will probably find it easier to lose weight or they may lose it faster, but the education is provided to all so no, I don’t think that skews the results. The study looks at losing 5-10% of their starting weight as success, although our experience has been much greater with this particular drug.
I tell patients I am considering 1/2 -2 lbs. per week for women and 1-2 lbs. per week for men, which is great success. The ultimate goal is to get patients to change or improve their food habits permanently. THAT IS THE REALLY HARD TASK.  A lot of what the Registered Dietician does is listening to the patient and helping them change behaviors one  step at a time. We do work on modifying behavior, hopefully for the better. The best patients are the ones that have realistic goals and have the time and energy to work on all this.
I do spend a fair amount of time going over all this with patients when I  call. I give them the rundown of what they can expect in terms of help from the Registered Dietician and nurses and what we expect of them. I gather some info from them as far as past attempts at dieting to try to judge their desire and readiness to stick with the study regardless if they get the active drug or not.


  • Ages 40+
  • BMI >27
  • No major medical changes in the last 4 weeks
  • To qualify for this study is very complicated. Make sure you read the above section about the study.
  • *Please note that other conditions may apply