About the Study

For many sufferers, migraines are a chronic disease that significantly diminishes their quality of life.  Migraines can begin by seeing dots, or flashing lights accompanied by severe headache pain for several hours. Many oral medications prescribed for migraine may upset your stomach, or worse, cause vomiting.

Rochester Clinical Research is conducting a study to evaluate the efficacy of the investigational nasal powder for the treatment of an acute migraine. The purpose of the study is to evaluate a new delivery system for an established migraine medication called dihydroergotamine, or DHE. The study will be a single intranasal dose and aims to give migraine symptom relief within two hours of taking the medication . Normally, when a medication is delivered through the nasal lining, the medication will act faster.

This study will last approximately three months with 3 visits to our office. Compensation is available for time and travel up to $150, for those who qualify, plus an additional $150 for diary compliance equaling to a total up to $300.


  • Between the ages of 18-65 years old
  • History of migraines (with or without aura) for more than one year with age of onset under 50.
  • 2-8 moderate to severe migraine attacks per month in each of the last 3 months
  • *Please note, other conditions may apply.