About The Study:

Nail fungus, also known as onychomycosis, is a common fungal infection that can affect the toenails and, less frequently, the fingernails. It typically begins as a small white or yellow spot under the nail and can progress to cause discoloration, thickening, and a brittle texture. While nail fungus is generally not painful, it can be unsightly and, if left untreated, may lead to more severe complications. Treatment options may include topical or oral antifungal medications, laser therapy, or, in severe cases, surgical removal of the affected nail. Since not all treatment approaches are effective or safe for everyone, it’s crucial to continuously explore and discover new treatment methods.

Rochester Clinical Research is actively looking for individuals aged 18-65 to join our ongoing nail fungus research study. The investigational product is a topical treatment, and to be eligible, you must have toenail fungus of one of your “big” toes. The study spans around 52 weeks and involves a series of 7 office visits. There is a 33% chance of placebo in this study. Compensation will be offered for your participation in the study.

Health insurance is not required nor needed to participate in our studies.


  • Must be between the ages of 18-65 years old
  • Have had toenail fungus for at least a year
  • Is willing to refrain from wearing nail polish on the affected toenail for a year
  • Have a fungal infection or what you think is a fungal infection of at least one great toenail
  • Must be willing to apply a topical product to your affected toe nail nightly
  • *Please note, other qualifications apply