Migraines: The Battle For A Cure

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On July 10th at the Strathallan Hotel, Dr. Joseph Mann and Rochester Clinical Research presented Migraines: The Battle for a Cure. Over 110 people came to hear Dr. Mann present as well as participate in a live question and answer portion of the evening. The presentation gave insight on why migraines occur, how migraines affects your life and available treatments options.

Migraines can take many forms, and many times individuals will refer their migraine as just a headache or pain. Migraines can be bilateral, unilateral, pulsing or non-pulsing. You can experience migraine pain in peripheral locations such as your neck or in your sinus area. Next, Dr. Mann discussed the migraine phases and the importance of identifying the earliest stages so you can avoid the advanced headache/migraine and postdrome phase.

Now that you can identify a migraine, what causes them? Dr. Mann reviewed two different causes including Cortical Spreading Depression (which occurs in clinically silent areas of the cortex) and dysfunction of brainstem nuclei which might exert a permissive role by favoring central trigeminal hyper-excitability.

Preventing migraines is the first form of treatment. The goal of prevention is to decrease the intensity and duration of pain and most bothersome symptoms. It allows the individual to decrease disability and use of acute medications.  Preventing also takes away the unpredictability. Unpredictability leads to stress and fear for future disruptive attacks which can result to a decrease in quality of life. Most importantly, prevent decreases the risk to turning your migraines into chronic migraines which may lead to changes in the brain.  Prevention can begin by learning what triggers your migraines, and avoiding them. Triggers can include stress, hunger, sleep disturbance, dehydration, diet, environmental stimuli, as well as changes in estrogen levels in women.

Treatment is a second options after prevention.  There are several FDA approved migraine treatments available on the market, however not everyone is a good candidate. Botox, Cefaly Tens Device, Triptans, and many others have been available. The newest approved migraine treatment is Aimovig (erenumab) which is a type of monoclonal antibody treatment. It resembles antibodies that the body naturally produces to bind to infectious pathogens. Since the CGRP widens blood vessels and can contribute to inflammation and pain transmission. Aimovig is delivered once a month with an EpiPen like injector. It works by the block the receptor for CGRP, reducing pain.  See below an illustration of how Aimovig works.

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As another care option, Rochester Clinical Research also addresses patient’s dissatisfaction with current preventatives and treatments. Our goal is to improve efficacy, provide better safety and tolerability, and provide faster onset and longer duration compared to current available medications. Right now, Rochester Clinical Research is offering several clinical research trials that may treat our migraines. Trials include a Natural Nasal Spray, an Oral migraine medication (a disolving tablet), an injection medication (once per month), and many other different trials coming up this fall. All of our studies do not require health insurance and compensation may be available for time and travel if you qualify. Each study has very specific inclusions exclusions to protect you and your health. Our Doctors and Nurses monitor your health closely and work with your primary care physician. Signing up is easy. Click on “RCR Studies – Currently Enrolling Studies” to see available studies. Find a study that interests you? See if you qualify by clicking the “See if you Qualify” button or call 585-288-0890 to speak with one of our recruiters.

Want to hear more from the event? Check out several of our Facebook Live Videos from the evening on our Facebook Page. 



RCR Helps Approval of Ebola Vaccine Use in DRC

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Rochester Clinical Research is proud to have helped approve the Merck Ebola Vaccination Clinical Trials. During the study, it was 100% successful leading to the approval of using it in the Democratic Republic of Congo where a deadly outbreak has occured resulting in 50 cases and 25 deaths this spring. Over 7,500 doses have been sent to the DRC which is expected to be extremely helpful in the outbreak. Emergency teams and the World Health Organization (WHO) are administering the vaccine which were donated by Merck to many individuals in the DRC, especially it’s capital.

A big thank you to all of our volunteers who helped make this study vaccine available to people in the Democrative Republic of Congo. It could not have happened without you.

Read more about Ebola Vaccination in DRC Here. 

 



“Migraines: The Battle for a Cure” on July 10 at 6PM at the Strathallen Hotel

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The battle is not over in finding the right preventative and treatment for disabling and frustrating migraine attacks. In the United States alone, over 37 million men, women and children live with the burden of unpredictable migraine attacks. “The majority of migraine sufferers do not get the relief they need from current migraine medications” states experienced Migraine Practitioner, Dr. Joseph Mann.  Rochester Clinical Research offers a multitude of treatment options, that are not yet available to the general public including different administered medications and devices that can make migraines less severe, reduce the frequency of migraine attacks and improve quality of life.

“Migraines: The Battle for a Cure” will discuss what causes migraines and what is being offered on the front lines here at Rochester Clinical Research as near-cures, alternative treatments and new devices that are available for thousands of sufferers. The event will be hosted on July 10th at 6:00PM at the Strathallen Hotel (550 East Avenue Rochester, NY). Registration will be required and space is limited to the first 150 registrants. Email your name, number attending and phone number to lgrizard@rcrclinical.com to register today or fill out the form below! 

Register Here:

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Currently available migraine medications, often bring negative side effects including nausea, vomiting or simply no relief. Rochester Clinical Research is conducting five investigational research studies each with a unique treatment prevention that may be better received in patients. These include an all-natural nasal spray. Similar to a probiotic, it enhances your immune system and can help prevent migraine headaches. Rochester Clinical Research also provides cutting-edge technology in migraine management with several device options controlled directly from your smart phone. There are a limited number of openings available to try these exclusive research study medication options, so migraine sufferers are encourage to attend  ”Migraines: The Battle for a Cure” to learn more and sign up.

 On May 31, 2018 the first medicine solely designed to prevent migraines was approved, ushering in a new era in the treatment of migraines. Rochester Clinical Research and nationally recognized neurologist and migraine specialist, Dr. Mann, are on the forefront in the search for similar new preventatives and acute treatments for the most common neurological disease. “It’s not just a headache. Migraines are still widely underdiagnosed and undertreated. If you have a disabling headache with nausea and light sensitivity, you most likely have a migraine” says Dr. Joseph Mann.

 If you suffer from migraines, this is an event you won’t want to miss. For more information or to register please call 585-288-0890.



Rochester Clinical Research Celebrates “Clinical Trial Day”

 

 

 

 

Happy Clinical Trial Day! 

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Everyone at Rochester Clinical Research celebrated Clinical Trial Day on Monday, May 21st. At RCR, we proudly conduct clinical research studies through our outstanding volunteers from Rochester, New York. The team loves being a part of Clinical Research because they not only are helping improve medicine but make a difference in many peoples’ lives.

Join the cause and volunteer today since volunteering for clinical research trials advances medicine and saves lives. 

We offer three easy steps to signing up:

1. Selecting a trial

2. Seeing if you qualify for the trial

3. Registering to begin the process

If you are new to the idea of volunteering for clinical trials, or to Rochester Clinical Research, you will probably want to know more. It’s all here on the website or give us a call at 585-288-0890.

If you have volunteered with us before, thank you for your dedication to tomorrow’s medicine. We hope to see you again soon.



Migraines with Mann

Dr. Joseph Mann is a board certified neurologist with a sub-specialty in headache medicine. We sat down with him and talked about Migraines. Check out his insights on everything migraines in this 5 part video series on our youtube page.

 

And be sure to see if you qualify for our current migraine studies



How informed consent removes the ‘guinea pig’ stigma from clinical research

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When, in 2016, Mary Dinnan, RPA-C retired from practicing primary care and joined the team at Rochester Clinical Research, she quickly realized how much her day-to-day work in private practice had been influenced by clinical research.

“I started to think — after having done primary care for 40 years — how much of what we do and did was the result of clinical trial work,” she said.

At RCR, clinical trials may involve vaccines for potential pandemics, but oftentimes they involve treatments for more commonplace conditions, including osteoarthritis, migraine or weight loss — things that may affect a friend, neighbor or loved one.

“These are normal issues that people deal with on a daily basis,” said Dinnan, adding that clinical research also informs recommendations doctors, Nurse Practitioners, and PAs give for common, potentially life-saving health screenings.

 “If I am advising someone to get a colonoscopy at 50, I don’t make that up — that is the result of somebody doing trials to determine when that type of intervention is necessary,” she said.

Dinnan is passionate about helping the public better understand the importance of clinical research — and breaking down the stigma that participants are “guinea pigs.”

All clinical trials include an in-depth process of learning key facts before an individual can decide to participate. Informed consent, as it’s called, continues throughout the study, said Dinnan.

“They have to understand what they’re signing up for,” she said. “And informed consent can be withdrawn at any time, so if you decide at any time that you no longer want to participate, it’s not a binding legal contract.”

Read full article here.



The Burdens of a Migraine

If you’ve ever tried to make it through a day of work or school with a headache, you know how much pain can disrupt your everyday routines. Now imagine having headache pain several times a month — or more. That’s a common occurrence for the 39 million Americans suffering from migraine, a neurological disease that can not only cause headache pain but also sensitivity to light and sound, extreme nausea, vomiting and disturbed vision.

“Migraines are more than just headaches,” said Dr. Joseph J. Mann, the Neurology and Headache Medicine Investigator at Rochester Clinical Research. Migraines involve both electrical and chemical processes in the brain, he said, causing excruciating pain, disability and burden upon sufferers.

According to the World Health Organization, migraine is the sixth leading cause of LYD (years living with disability) worldwide, and a 2015 study found that migraine and headaches are leading causes of both outpatient and emergency room visits in the US. And yet, there are only four preventative migraine treatments approved by the US Food and Drug Administration. Mann and his colleagues are working to increase that number.

Full Article here



How Healthy Volunteers Shape Medicine’s Future

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Everyday heroes — that’s the name that Dr. Matthew Davis and his team at Rochester Clinical Research have for those who participate in their clinical research studies. RCR’s research on these healthy adults helps prevent, detect, diagnose, control and treat illnesses.

“We’re always in need of healthy people willing to help out their fellow man,” said Davis of the work he has done at RCR for the last two decades. “There’s really no medical progress made unless healthy volunteers step up to the plate and volunteer to try new things.”

Whether it’s a vaccine to prevent a potential avian flu pandemic or a new diabetes medication, every treatment is tested in healthy adults before being used in affected populations, said Davis, RCR’s medical director. Since 1994, more than 10,000 healthy volunteers have helped RCR in more than 600 clinical research studies.

Participating in a clinical trial is not time-consuming or difficult, though each study differs, according to RCR. Studies range from months up to a year or sometimes more. However, volunteers, who are compensated for their time, find the study takes less time as it goes on. Davis said that the first appointment — with sessions on informed consent to go over any risks and side effects, a comprehensive medical exam and laboratory testing — may take 90 minutes to two hours, while subsequent visits may take only 10 to 20 minutes every few weeks or month.

Volunteers not only actively support their own health care, but they also help others — perhaps even a friend, neighbor or loved one — by being a part of ground-breaking medical research. On a personal level, they have access to new research and treatments not yet available to the public.

“They’re helping the rest of us,” Davis said. That’s also what motivated Davis, a board-certified family physician and Air Force active-duty veteran, to become a researcher. “You feel like you’re part of a bigger picture,” said Davis, who has been a principal investigator or sub-investigator in more than 500 studies.

Some of the diseases Davis and RCR studies — like Dengue fever or Zika virus — are rarely if ever found in Rochester or much of the United States. But studies of those diseases also require healthy adult volunteers.

 He cites an outbreak that did affect the US, the Spanish flu of 1918 and 1919. That pandemic killed more than 50 million worldwide and infected more than 10 times that many, according to the Centers for Disease Control and Prevention. While most Americans weren’t alive to remember that outbreak, it’s not one we should forget, said Davis. “Most experts say it will happen again at some point — the question is when,” he said.

Davis emphasizes the important role that volunteers play in these and all studies RCR conducts. No matter how long research has been going on, no matter how much promise a drug or treatment may have, it all stops without healthy volunteers. Every study needs enough volunteers to statistically determine whether something is a good treatment, which is why Davis reiterates how unselfish such participation is.

“Really, they are doing something that may not benefit them directly, but may have an impact five, 10 years down the line,” he said.



How to Find Arthritis Relief

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Cold weather can really do a number on the already painful aches of arthritis. Below are a few tips to finding arthritis relief this winter.

  1. Dress Safe and Warm
    Keep aching hands in gloves, add layers over knees and legs. If you’re going outside wear solid, supportive shoes with good treads and avoid icy surfaces.
  2. Stay Hydrated
    Even mild dehydration might make you more sensitive to pain. You can also find relief from a warm bath or swimming pool, but don’t go right out in the cold afterwards – let your body’s temperature normalize a bit.
  3. Stay Active
    Winter seems like a great time to “hibernate” but staying active can really help your arthritis. Many people find that as their activity levels go up, and weight goes down, their arthritis improved. Try to come up with an indoor exercise plan – treadmills or elipticals, or even a walk at the mall.
  4. Take your vitamins
    Low levels of Vitamin D could be adding to your pain. There are many other supplements that have been successful in helping with arthritis pain as well, from fish oil to acetaminophen. Consult your doctor to find the right thing for you.
  5. Seek treatment
    Visit a doctor, get a massage, try acupuncture, or participate in a clinical trial – find what works for you.

Rochester Clinical Research has several currently enrolling clinical trials for those suffering from arthritis. See if you qualify today!



10 Tips and Tricks to Avoid the Flu

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With such a severe flu season this year. Here are 10 tips and tricks to prevent the spread of germs brought to you by the CDC!

  1. Avoid close contact to anyone who is sick
  2. Don’t be a hero – if you are sick, stay home from work or school!
  3. Cover your mouth and nose when you sneeze or cough
  4. Clean your hands often – soap and water or alcohol-based hand rub will do
  5. Avoid touching your eyes, nose, or mouth when possible
  6. Keep surfaces clean at your home, work, or school
  7. Drink plenty of fluids
  8. Eat nutritious foods
  9. Get plenty of sleep
  10. Find ways to manage your stress

Interested in participating in a universal vaccine study? Click here for more information!



‘Tis the season of giving at RCR!

Christmas Spirit is in the air at Rochester Clinical Research. This year, RCR partnered with Mary Cariola Children’s Center to give one family a spectacular Christmas filled with lots of gifts! With over 30 gifts generously donated by our staff, we hope to spread the Christmas Cheer to those less fortunate than us. Happy Holidays from Rochester Clinical Research!

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Patient Spotlight: Gayle

Rochester Clinical Research has amazing volunteers that help to advance medicine for the future. RCR would like to put a spotlight on our volunteers to show our appreciation!

Meet Gayle! As a long time sufferer of migraines, Gayle participated in a migraine study that RCR conducted this past year.



New Research being conducted to Prevent the Most Common Cause of Hospital-acquired infection.

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Clostridium difficile (C. diff) is one of the most common causes of healthcare-related infections. It is estimated that each year in the United States, about a half million people get sick from C. difficile, and in recent years, C. difficile infections have become more frequent, severe, and difficult to treat.

C. diff is a type of bacteria that lives in the human intestines. Its spores can survive outside of the body for months. These spores are resistant to cleaning and are most commonly transmitted in healthcare settings. People can become infected by touching surfaces that are contaminated or by coming into contact with a healthcare worker that has the bacteria or spores on their hands.

People most at risk of getting sick due to C. diff are those who are taking antibiotics, being treated in a healthcare facility, the elderly and people who are already ill. This infection can cause symptoms that include frequent diarrhea, inflammation of the colon, fever, nausea and abdominal pain; in severe cases it can be life-threatening.

Rochester Clinical Research is conducting a study to evaluate the safety and efficacy of an investigational vaccine in reducing the chances of getting sick due to C. diff. The knowledge gained from this study may help others in the future. Eligible participants will receive study related tests and procedures at no cost and compensation may be available.  Call 585-288-0890 or email volunteer@rcrclinical.com to learn how you can help contribute to this important research study.

Check out our C. Diff study spotlight on WXXI News.



Patient Spotlight: Roselyn

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RCR: How many/what studies have you participated in?

Roselyn: I’ve done 3-4 over a few years. The last one I remember was a study on a daily injection for Osteoporosis where I ended up being one of the people to get the placebo.

RCR: Why did you initially decide to participate in this study?

Roselyn: I’m a very altruistic person. I believe when I leave this world I will take my body with me, so I’d like to use it to help humanity while I am still here.

RCR: What did you enjoy about the study?

Roselyn: Nothing was difficult, everything was easy from start to finish

RCR: Is there anything that stuck out to you about RCR specifically?

Roselyn: The Nurses were very professional and gentle.

RCR: What would you like to say to people who are hesitant about Clinical Trials?

Roselyn: That they are helping the future. They are helping future generations not have to deal with diseases that we’ve dealt with in the past.



RCR Commercial

Check out our latest commercial

Produced in collaboration with Sundance Marketing, this video titled You and Me, represents what Rochester Clinical Research is all about, our volunteers. Without our loyal volunteers, we would be unable to live out our mission of – Advancing Medicine and Changing Lives.



Saying “It’s too late for me to quit smoking” is just an excuse

smoke

20 Minutes after quitting

your heart rate drops to a normal level

12 hours after quitting

the carbon monoxide level in your blood drops to normal

2 weeks – 3 months after quitting

your risk of having a heart attack drops and your lung function improves

1-9 months after quitting

your coughing and shortness of breath decrease

1 year after quitting

your added risk of coronary heart disease is half that of current smokers

5-15 years after quitting

your risk of having a stroke is half that of a smoker’s and your risk of getting cancer of the mouth, throat, or esophagus is half that of a smoker’s

10 years after quitting

your risk of getting bladder cancer or dying from lung cancer is about half that of a smoker’s. your risk of getting cervical cancer or cancer of the larynx, kidney or pancreas decreases

15 years after quitting

your risk of coronary heart disease is the same as that of a non smoker


Contact Rochester Clinical Research for more information on tips and tricks to quitting smoking 585-288-0890 or Text “info” to 87888



Local Neurologist and Headache Specialist, Dr. Joseph Mann and Rochester Clinical Research Join Forces

Dr. Joseph Mann, recipient of 2016 Headache Practitioner of the Year Award, has joined on as part of the Rochester Clinical Research staff.

Rochester, NY– Rochester Clinical Research is proud to announce that Dr. Joseph Mann, a prominent Rochester neurologist, has joined on as part of the staff. Dr. Mann was recently awarded the 2016 Headache Practitioner of the Year Award by the National Headache Society. Dr. Mann is board certified in both neurology and psychiatry and has sub-specialty certification in Headache Medicine.

With this new addition, Rochester Clinical Research will be able to not only continue with its long history of migraine research, but explore new areas of migraine research and other neurological and psychiatric areas such as: ADD, mild depression, mild cognitive impairment, as well as other headache disorders.

“We couldn’t be more proud to have Dr. Joseph Mann as part of the RCR staff. He’s an incredibly gifted neurologist and we’ve always admired the work he does and the relationships that he builds with his patients and colleagues. I look forward to working more closely with him and pursuing new and exciting opportunities” said Adam Larrabee, President of Rochester Clinical Research.

About Rochester Clinical Research

RCR was founded in 1994 to provide residents of the Greater Rochester Area access to clinical research studies and advance new medical treatments. Our unwavering commitment to providing efficient, friendly and caring service has helped us in becoming one of the leading research sites in the United States, noted for a large, loyal group of volunteers and frequent studies. RCR has conducted more than 650 research studies, involving more than 15,000 volunteers. For more information, visit www.RCRclinical.com.



Protected: 5 Questions and Answers: C. Difficile

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What do you really know about C. Diff? 90% of deaths related to C. Diff occur in individuals who are 65 years of age and older, and 1 in 5 people who are infected have recurring infections. In total, C. Diff accounts for roughly 14,000 deaths per year. Read on to learn more about C. Diff and an opportunity to help find a vaccine.

  1. How can you get C. Diff?
    1. Well, those at the highest risk are the elderly population, and those taking antibiotics. Most C. Diff cases are a result of ineffective, or lack of infection prevention and control measures.
  2. How do you know if you have it?
    1. Symptoms include fever, lack of appetite, nausea, watery diarrhea, and abdominal pain/tenderness.
  3. How does taking antibiotics contribute to C. Difficile?
    1. Elevated doses of certain antibiotics used over an extended period of time can increase the probability of contracting a C. Diff infection because antibiotics change the composition of bacteria in the gut. When there are fewer bacteria in the gut, it creates room for C. Diff to come in and produce toxins.
  4. How can you prevent C. Diff?
    1. Careful use of antibiotics, and taking the necessary infection prevention and control measures.
  5. Is C. Diff fatal?
    1. Diff can cause mild diarrhea, to life-threatening conditions such as: bowel perforation, sepsis, and even death.

Rochester Clinical Research is now seeking interested volunteers for an investigational study for a C. Diff vaccine. If you’re 50 years of age or older and fall within one or more of the categories below, you may qualify.

  • Visited the hospital at least once within the past 12 months, for 2 or more nights
    OR
  • Visited the emergency room at least twice within the past 12 months
    OR
  • Visited the doctors at least 12 times within the past 12 months
    OR
  • Live in a nursing facility
    OR
  • Taken an antibiotic within the past 3 months
  • Cannot have had C. Diff
  • **Please note, other conditions may apply**

Please click on the link below or call 585-288-0890 to learn more or see if you qualify.

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Ebola Vaccine – 100% Protection During Clinical Trial

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It’s great to see progress being made in the clinical research industry! An article released 12/23/16 via Beckers Hospital Review highlights great strides being made in Ebola Vaccine research. A study on a new, experimental vaccine displayed 100% efficacy during clinical trials involving thousands of subjects in Guinea, Africa.

Interested in reading more? Follow the link below!

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Americas become first region to eliminate measles

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Reuters: After a 22-year vaccination effort against the measles, the Pan American Health Organization said on Tuesday that The Americas has become the first region in the world to have eradicated measles. This is a tremendous accomplishment, given that measles continues to infect tens of thousands of people on a global scale.

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